Studio finanziato dalla Brain Research Foundation Verona.

Articolo pubblicato online il 13 ottobre 2021:

© 2021 The Author(s). Published by Communications Medicine


Luca Dalle Carbonare, Maria Teresa Valenti, Zeno Bisoffi, Chiara Piubelli, Massimo Pizzato, Silvia Accordini, Sara Mariotto, Sergio Ferrari, Arianna Minoia, Jessica Bertacco, Veronica Li Vigni, Gianluigi Dorelli, Ernesto Crisafulli, Daniela Alberti, Laura Masin, Natalia Tiberti, Silvia Stefania Longoni, Lucia Lopalco, Alberto Beretta, Donato Zipeto.


Background The antibody response to SARS-CoV-2 mRNA vaccines in individuals with waning immunity generated by a previous SARS-CoV-2 infection, as well as the patterns of IgA and IgM responses in previously infected and in naïve individuals are still poorly understood.
Methods We performed a serology study in a cohort of BTN162b2 mRNA vaccine recipients who were immunologically naïve (N, n = 50) or had been previously infected with SARSCoV-2 (P.I., n = 51) during the first (n = 25) or second (n = 26) pandemic waves in Italy, respectively. We measured IgG, IgM and IgA antibodies against the SARS-CoV-2 Spike (S)and IgG against the nucleocapsid (N) proteins, as well as the neutralizing activity of sera collected before vaccination, after the first and second dose of vaccine.
Results Most P.I. individuals from the first pandemic wave who showed declining antibody titres responded to the first vaccine dose with IgG-S and pseudovirus neutralization titres that were significantly higher than those observed in N individuals after the second vaccine dose. In all recipients, a single dose of vaccine was sufficient to induce a potent IgA response that was not associated with serum neutralization titres. We observed an unconventional pattern of IgM responses that were elicited in only half of immunologically naïve subjects even after the second vaccine dose.
Conclusions The response to a single dose of vaccine in P.I. individuals is more potent than that observed in N individuals after two doses. Vaccine-induced IgA are not associated with serum neutralization.

Responsabile: prof. Donato Zipeto – Università degli Studi di Verona

Articolo open access con licenza Creative Commons Attribution 4.0.

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